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Post-doctoral research assistant required

Job description
This research will involve the design, engineering, production, purification and characterisation of recombinant antibodies which recognise prostate cancer cells.
Chemical photosensitisers will be coupled to the antibodies to generate a range of photo-immunoconjugates capable of killing cancer cells using the approach known as ‘Photodynamic Therapy’. Techniques such as bacterial and mammalian cell culture, protein chemistry, affinity chromatography, fluorescence microscopy, FACS, surface plasmon resonance, photo-physical measurements, cell cytotoxicity assays, radioisotope labelling and pre-clinical studies will be used.

The post will involve the writing of manuscripts, patent applications research grants and research presentations.

Regular presentation of research progress is required, accurate and detailed laboratory notebook keeping and some minor supervision of undergraduate and post-graduate project students is also required. Some laboratory organisational duties will be carried out such a ordering supplies, lab tidying, health and safety maintenance.

The post is for 37.5 hours per week with some occasional weekend work (time off in lieu given). The post will be held at Imperial College London, South Kensington Campus.

Summary of the Post:
Post-doctoral researcher developing novel prostate cancer drugs.

Key Responsibilities:

• Produce, purify and characterise antibody-based therapeutic molecules.
• Maintain cancer cell lines for above task.
• Assist in training new graduate, masters and undergraduate students.
• Develop and drive the research project forward.
• Maintain a database of relevant published work.
• Collect high quality data for publication and patenting.
• Be involved in preparing presentations, manuscripts and grant applications.
• Train other members of the group in a variety of tasks.
• Assist in the running of the lab, ordering supplies, lab organization.

Person specification
This research post is ideally suited to someone who has recently completed his/her Phd studies. The thesis must have been submitted before commencing post. A person with experience in at least half of the techniques described above particularly protein engineering and mammalian cell manipulation. The person must be able to work well in a laboratory team as well as have the capacity for independent research and responsibility.

Please contact Dr Mahendra Deonarain for further details